Clinical Trials

A great way to help others and yourself!

Pentucket Medical, in our continuing efforts to improve and offer advanced treatments, is involved in several clinical trials and is currently enrolling participants.

NOTE: This is a list of currently active trials. For a list of completed trials / research, please visit our Completed Trials page.

Clinical trials are entirely voluntary and patients may withdraw at any time, for any reason. We are currently participating in the following studies (More info is avalable for most trials. Please click on the title to learn more.):

Eligibility

To find out whether you are eligibile to participate in one of these studies, please contact the Clinical Research Office at (978) 521-3288

Active Studies

ACCELERATE
Assessment of Clinical Effects of Cholesteryl Ester Transfer Protein Inhibition with Evacetrapib in Patients at a High-Risk for Vascular Outcomes.

AMGEN LDL STUDY
A double-blind, randomized, placebo-controlled, multicenter study assessing the impact of additional ldl-chloesterol reduction on major cardiovascular events when used in combination with statin therapy in patients with clinically evident cardiovascular disease

CANTOS Trial
A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in the prevention of recurrent cardiovascular events among stable post-myocardial infarction patients with elevated hsCRP

CIRT TRIAL
A Randomized, Double-blind, Placebo-controlled, Event-driven trial of Weekly Low-dose Methotrexate (LDM) in the Prevention of Recurrent Cardiovascular Events Among Stable Post-Myocardial Infraction Patients with Type 2 Diabetes or Metabolic Syndrome.

COMPASS TRIAL

A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patient with Coronary or Peripheral Artery Disease ( COMPASS-Cardiovascular OutocoMes for People Using Anticoagulation StrategieS)

DECLARE TRIAL 

A Randomized Controlled Trial of Rivaroxaban for the Prevention of Major Cardiovascular Events in Patient with Coronary or Peripheral Artery Disease ( COMPASS-Cardiovascular OutocoMes for People Using Anticoagulation StrategieS)

EUCLID TRIAL

A Randomized, Double-blind, Parallel Group, Multicentre Phase IIIb Study to Compare Ticagrelor with Clopidogrel treatment on the Risk of Cardiovascular Death, Myocardial Infarction and Ischemic Stroke in Patients with Established Peripheral Artery Disease (EUCLID Examining Use of tiCagreLor in paD)

PEGASUS TRIAL

Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients with Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin (PEGASUS)

SONAR TRIAL

A Randomized, Multicountry, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes and Nephropathy with Atrasentan.

Trials Closed to Enrollment

Currently in Follow up phase:

MPROVE IT

Study to Establish the Clinical Benefit/Safety of Vytorin (Esetimibe/Simvastatin Tablet) vs Simvastatin in Subjects with Acute Coronary Syndrome (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial-IMPROVE IT)

PARADIGM Trial
A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure and reduced ejection fraction

REVEAL-TIMI-55 Trial
Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification. A Large-scale, Randomized Placebo-controlled Trial of the Clinical Effects of Anacetrapib Among People With Established Vascular Disease.